"I suggest going out to the nearest pub and getting completely, and utterly, wasted. Make sure you smoke at least 1 pack of unfiltered Camel's. Get the full ashtray, pour a drink in it and then pour the mixture into a water bottle.
When you get home (ideally around 3:30am) stick the vile mixture into your freezer. Put on your best goretex and thermal layer. Climb in. At 5:30am, get out, drink (chew?) the mixture and go run the biggest flight of stairs you can find. Run until your heart threatens to explode.
Your dehydration caused by the alcohol should adequately simulate what you may experience at higher altitudes. Your lung capacity should be sufficiently impaired by the smokes to simulate a oxygen poor environment. The freezer episode should adequately replicate a bivy. Drinking the booze/butt mixture should simulate your lack of appetite.....
Oh — once your finished your workout, go to work (to replicate the long walk out)." — Greg Hamilton suggesting an altitude training methodology.